Research Paper Volume 13, Issue 10 pp 14001—14014

Adalimumab ameliorates memory impairments and neuroinflammation in chronic cerebral hypoperfusion rats

ADA rescued memory impairments in CCH rats. (A) The escape latency to find the visible platform in the first 3 days. (B) Representative traces of rats given different treatments on day 5 of the training phase. (C) Escape latency to find the hidden platform on days 1-5 of the training phase. (D) The swimming speeds of the different groups in the training phase. (E) Representative traces of rats given different treatments in the probe trial. (F) The total amount of time spent in the target quadrant in the probe trial. (G) The number of platform region crossings in the probe trial. (H) The latency to first platform region crossing in the probe trial. All values are expressed as the mean ± SEM (n = 10). **p ##p

Figure 2. ADA rescued memory impairments in CCH rats. (A) The escape latency to find the visible platform in the first 3 days. (B) Representative traces of rats given different treatments on day 5 of the training phase. (C) Escape latency to find the hidden platform on days 1-5 of the training phase. (D) The swimming speeds of the different groups in the training phase. (E) Representative traces of rats given different treatments in the probe trial. (F) The total amount of time spent in the target quadrant in the probe trial. (G) The number of platform region crossings in the probe trial. (H) The latency to first platform region crossing in the probe trial. All values are expressed as the mean ± SEM (n = 10). **p < 0.01 vs. the sham group; ##p < 0.01 vs. the CCH group.