Research Paper Volume 13, Issue 10 pp 14001—14014

Adalimumab ameliorates memory impairments and neuroinflammation in chronic cerebral hypoperfusion rats

ADA rescued neuronal loss in CCH rats. (A) Representative images of Nissl staining for the different groups. Left: the whole hippocampus; Right: magnified images of the CA1, CA3 and DG regions. Bar = 100 μm for the left panel and 20 μm for the right panel. (B–D) Quantification of neuron number in the different groups in the CA1 (B), CA3 (C) and DG (D) regions. All values are expressed as the mean ± SEM (n = 8). **p ##p

Figure 3. ADA rescued neuronal loss in CCH rats. (A) Representative images of Nissl staining for the different groups. Left: the whole hippocampus; Right: magnified images of the CA1, CA3 and DG regions. Bar = 100 μm for the left panel and 20 μm for the right panel. (BD) Quantification of neuron number in the different groups in the CA1 (B), CA3 (C) and DG (D) regions. All values are expressed as the mean ± SEM (n = 8). **p < 0.01 vs. the sham group; ##p < 0.01 vs. the CCH group.