Research Paper Volume 13, Issue 9 pp 13264—13286

Tumor-derived exosomal circRNA_102481 contributes to EGFR-TKIs resistance via the miR-30a-5p/ROR1 axis in non-small cell lung cancer


Figure 8. circRNA_102481 serves as a miR-30a-5p sponge to regulate ROR1 expression. The detailed potential binding sequences of circRNA_102481 to miR-30a-5p (A) and ROR1 to miR-30a-5p (D). miR-30a-5p of PC9/GR and HCC827/ER cells was abundantly pulled down by circRNA_102481 (B) or ROR1 (E). Dual-luciferase reporter assay confirmed that miR-30a-5p competitively targeted circRNA_102481(C), and that ROR1 is a direct target of miR-30a-5p (F). #p > 0.05, *p< 0.05, **p<0.01.