Research Paper Volume 13, Issue 9 pp 13264—13286

Tumor-derived exosomal circRNA_102481 contributes to EGFR-TKIs resistance via the miR-30a-5p/ROR1 axis in non-small cell lung cancer

Effects of exosomes on circRNA

Figure 9. Effects of exosomes on circRNA_102481-miR-30a-5p-ROR1 Axis. (A, B) RT-qPCR assay showed miR-30a-5p expression in PC9/GR or HCC827/ER cells of si-NC and si-circRNA_102481 groups. (C) Transfection efficiency of miR-30a-5p mimic and miR-30a-5p inhibitor was verified by RT-qPCR assay. **p<0.01 versus miR-30a-5p NC group cells. (D, E) qRT-PCR demonstrated that ROR1 mRNA expression were significantly decreased in miR-30a-5p mimic group, and increased in miR-30a-5p inhibitor group. *p<0.05, **p<0.01 versus miR-30a-5p NC group.