Research Paper Volume 13, Issue 9 pp 13300—13317

SnoRD126 promotes the proliferation of hepatocellular carcinoma cells through transcriptional regulation of FGFR2 activation in combination with hnRNPK

SnoRD126 mutants did not change the rate of tumour growth in vivo. (A) The xenograft tumours photograph after stably overexpressing snoRD126 and its mutants in Huh7 cells. (B) Overexpressing snoRD126, not the mutants, increased tumour volume. (C) Overexpressing snoRD126, not the mutants, increased tumour weights. (D) WB assay was used to analyze the changes of the indicated protein levels in tumours. (E) qRT-PCR assay for FGFR2 expression in tumours. (F) Immunohistochemistry showing snoRD126 overexpressing led to an increase of Ki67 protein and phosphorylation of AKT levels rather than its mutants. mean ± SD, *P

Figure 5. SnoRD126 mutants did not change the rate of tumour growth in vivo. (A) The xenograft tumours photograph after stably overexpressing snoRD126 and its mutants in Huh7 cells. (B) Overexpressing snoRD126, not the mutants, increased tumour volume. (C) Overexpressing snoRD126, not the mutants, increased tumour weights. (D) WB assay was used to analyze the changes of the indicated protein levels in tumours. (E) qRT-PCR assay for FGFR2 expression in tumours. (F) Immunohistochemistry showing snoRD126 overexpressing led to an increase of Ki67 protein and phosphorylation of AKT levels rather than its mutants. mean ± SD, *P<0.05, **P<0.01.