Research Paper Volume 13, Issue 11 pp 14940—14967

Identification of key transcriptome biomarkers based on a vital gene module associated with pathological changes in Alzheimer’s disease

Identification of the target module. (A) Heatmap of the correlations between MEs and clinical traits of AD. Each cell contains the correlation coefficient and p-value (within brackets). (B, C) Scatter plots of GS value of plaque score (B) and BRAAK stage (C) vs. the MM value of each gene in the target module. (D) Heatmap of genes in the target module of entorhinal cortex samples in GSE118553. (E) Heatmap of genes in the target module of hippocampus samples in GSE48350. AsymAD, asymptomatic AD.

Figure 1. Identification of the target module. (A) Heatmap of the correlations between MEs and clinical traits of AD. Each cell contains the correlation coefficient and p-value (within brackets). (B, C) Scatter plots of GS value of plaque score (B) and BRAAK stage (C) vs. the MM value of each gene in the target module. (D) Heatmap of genes in the target module of entorhinal cortex samples in GSE118553. (E) Heatmap of genes in the target module of hippocampus samples in GSE48350. AsymAD, asymptomatic AD.