Research Paper Volume 13, Issue 11 pp 14940—14967

Identification of key transcriptome biomarkers based on a vital gene module associated with pathological changes in Alzheimer’s disease

Circular visualization of connectivity, expression patterns, and chromosomal positions of the 100 genes with the highest MM value in the target module. The expression profiles of control (outer ring) and AD (inner ring) individuals of GSE29378 were presented in the circular heatmap. “Red” indicates upregulation, “blue” represents downregulation, and “white” denotes genes that are not present in a given dataset. The outer circle represents chromosomes; lines coming from each gene point to their specific chromosomal locations. The ten genes with the highest MM value were shown in green font and they were connected with green lines in the center of the circles.

Figure 2. Circular visualization of connectivity, expression patterns, and chromosomal positions of the 100 genes with the highest MM value in the target module. The expression profiles of control (outer ring) and AD (inner ring) individuals of GSE29378 were presented in the circular heatmap. “Red” indicates upregulation, “blue” represents downregulation, and “white” denotes genes that are not present in a given dataset. The outer circle represents chromosomes; lines coming from each gene point to their specific chromosomal locations. The ten genes with the highest MM value were shown in green font and they were connected with green lines in the center of the circles.