Research Paper Volume 13, Issue 11 pp 14940—14967

Identification of key transcriptome biomarkers based on a vital gene module associated with pathological changes in Alzheimer’s disease

Expression and functional analyses of MEG3, miR-106a-3p and miR-24-3p. (A–C) The expression of MEG3, miR-106a-3p, and miR-24-3p in the hippocampus of 5XFAD mice and LM mice determined by qRT-PCR assay. (D–F) The expression of MEG3, miR-106a-3p, and miR-24-3p in the hippocampus of 5XFAD mice of various ages determined by qRT-PCR assay. (G–I) KEGG pathway analysis of target genes of MEG3, miR-106a-3p, and miR-24-3p. Data were presented as the mean ± SD of five mice in each group. * p p p

Figure 7. Expression and functional analyses of MEG3, miR-106a-3p and miR-24-3p. (AC) The expression of MEG3, miR-106a-3p, and miR-24-3p in the hippocampus of 5XFAD mice and LM mice determined by qRT-PCR assay. (DF) The expression of MEG3, miR-106a-3p, and miR-24-3p in the hippocampus of 5XFAD mice of various ages determined by qRT-PCR assay. (GI) KEGG pathway analysis of target genes of MEG3, miR-106a-3p, and miR-24-3p. Data were presented as the mean ± SD of five mice in each group. * p < 0.05, ** p < 0.01 and **** p < 0.0001.