Research Paper Volume 13, Issue 10 pp 14065—14077

TCF-3-mediated transcription of lncRNA HNF1A-AS1 targeting oncostatin M expression inhibits epithelial-mesenchymal transition via TGFβ signaling in gastroenteropancreatic neuroendocrine neoplasms

HNF1A-AS1 inhibited cellular invasion targeting OSM. (A–B) Totally of 280 discrepant coding genes were identified by GeneChip array analysis. (C) Receptor binging was found as one of the top ten GO terms in the molecular function analysis. (D) In cellular component analysis, extracellular space was the most represented component. (E) OSM expression was the most discrepant gene following dys-regulation of HNF1A-AS1 in QGP-1 cells by qRT-PCR. (F–G) OSMR-β and OSM expression was tested in STC-1 cells and human samples by qRT-PCR. (H) Transwell was performed to analyze the effect of OSM on cell migration and invasion. *p **p

Figure 7. HNF1A-AS1 inhibited cellular invasion targeting OSM. (AB) Totally of 280 discrepant coding genes were identified by GeneChip array analysis. (C) Receptor binging was found as one of the top ten GO terms in the molecular function analysis. (D) In cellular component analysis, extracellular space was the most represented component. (E) OSM expression was the most discrepant gene following dys-regulation of HNF1A-AS1 in QGP-1 cells by qRT-PCR. (FG) OSMR-β and OSM expression was tested in STC-1 cells and human samples by qRT-PCR. (H) Transwell was performed to analyze the effect of OSM on cell migration and invasion. *p < 0.05, **p < 0.01.