Research Paper Volume 13, Issue 10 pp 14078—14087

Circular RNA ABCB10 contributes to laryngeal squamous cell carcinoma (LSCC) progression by modulating the miR-588/CXCR4 axis

CircABCB10 promotes the tumor growth of LSCC in vivo. (A–E) The effect of circABCB10 on tumor growth of LSCC cells in vivo was analyzed by nude mice tumorigenicity assay by injected with the AMC-HN-8 cells treated with control shRNA or circABCB10 shRNA. (A) Representative images of dissected tumors from nude mice were presented. (B) The average tumor volume was calculated and shown. (C) The average tumor weight was calculated and shown. (D) The expression levels of miR-588 were measured by qPCR in the tumor tissues of the mice. (E) The protein expression of CXCR4 and β-actin was assessed by Western blot analysis in the tumor tissues of the mice. N = 5. Data are presented as mean ± SD. Statistic significant differences were indicated: **P

Figure 6. CircABCB10 promotes the tumor growth of LSCC in vivo. (AE) The effect of circABCB10 on tumor growth of LSCC cells in vivo was analyzed by nude mice tumorigenicity assay by injected with the AMC-HN-8 cells treated with control shRNA or circABCB10 shRNA. (A) Representative images of dissected tumors from nude mice were presented. (B) The average tumor volume was calculated and shown. (C) The average tumor weight was calculated and shown. (D) The expression levels of miR-588 were measured by qPCR in the tumor tissues of the mice. (E) The protein expression of CXCR4 and β-actin was assessed by Western blot analysis in the tumor tissues of the mice. N = 5. Data are presented as mean ± SD. Statistic significant differences were indicated: **P < 0.01.