Research Paper Volume 13, Issue 10 pp 14131—14158

Downregulation of USP18 reduces tumor-infiltrating activated dendritic cells in extranodal diffuse large B cell lymphoma patients

The DETFs between EN and LN DLBCL. (A) The heatmap and (B) volcano plot of 7 DETFs; (C) The box plot to show expression of CCL1 between EN and LN DLBCL; (D) The box plot to show expression of IFNA21 between EN and LN DLBCL; (E) The box plot to show expression of USP18 between EN and LN DLBCL; (F) The Venn plot to show overlap of ENI- and DETFs- related immune genes. Abbreviations: DETFs, Differentially expressed transcription factors; CCL1, C-C motif chemokine ligand 1; IFNA21, Interferon alpha-21; USP18, Ubiquitin specific peptidase 18; ENI, Extranodal involvement.

Figure 4. The DETFs between EN and LN DLBCL. (A) The heatmap and (B) volcano plot of 7 DETFs; (C) The box plot to show expression of CCL1 between EN and LN DLBCL; (D) The box plot to show expression of IFNA21 between EN and LN DLBCL; (E) The box plot to show expression of USP18 between EN and LN DLBCL; (F) The Venn plot to show overlap of ENI- and DETFs- related immune genes. Abbreviations: DETFs, Differentially expressed transcription factors; CCL1, C-C motif chemokine ligand 1; IFNA21, Interferon alpha-21; USP18, Ubiquitin specific peptidase 18; ENI, Extranodal involvement.