**Figure 4.** **The DETFs between EN and LN DLBCL.** (**A**) The heatmap and (**B**) volcano plot of 7 DETFs; (**C**) The box plot to show expression of CCL1 between EN and LN DLBCL; (**D**) The box plot to show expression of IFNA21 between EN and LN DLBCL; (**E**) The box plot to show expression of USP18 between EN and LN DLBCL; (**F**) The Venn plot to show overlap of ENI- and DETFs- related immune genes. Abbreviations: DETFs, Differentially expressed transcription factors; CCL1, C-C motif chemokine ligand 1; IFNA21, Interferon alpha-21; USP18, Ubiquitin specific peptidase 18; ENI, Extranodal involvement.