Research Paper Volume 13, Issue 9 pp 12378—12394

Transcriptomic profile of the mice aging lung is associated with inflammation and apoptosis as important pathways

Identification of top enriched diseases and disorders related pathways of old versus young mice lungs using IPA Z-score algorithm. (A) Diseases and disorders category. (B) Percentage contribution of dysregulates pathways affecting the respiratory disease subcategory. (C) TNF interaction network. Colored nodes refer to genes found in our dataset (green downregulated; red upregulated). Uncolored nodes were not identified as differentially expressed in our experiment and were integrated into the computationally generated IPA networks.

Figure 2. Identification of top enriched diseases and disorders related pathways of old versus young mice lungs using IPA Z-score algorithm. (A) Diseases and disorders category. (B) Percentage contribution of dysregulates pathways affecting the respiratory disease subcategory. (C) TNF interaction network. Colored nodes refer to genes found in our dataset (green downregulated; red upregulated). Uncolored nodes were not identified as differentially expressed in our experiment and were integrated into the computationally generated IPA networks.