Research Paper Volume 13, Issue 9 pp 12378—12394

Transcriptomic profile of the mice aging lung is associated with inflammation and apoptosis as important pathways

Identification of top enriched molecular and cellular functions related pathways of old versus young mice lungs using IPA Z-score algorithm. (A) Molecular and cellular functions category. (B) Percentage contribution of affected pathways in cell death and survival subcategory. Colored nodes refer to genes found in our dataset (green means downregulated; red means upregulated). Uncolored nodes were not identified as differentially expressed in our experiment and were integrated into the computationally generated IPA networks to indicate relevance to this network.

Figure 3. Identification of top enriched molecular and cellular functions related pathways of old versus young mice lungs using IPA Z-score algorithm. (A) Molecular and cellular functions category. (B) Percentage contribution of affected pathways in cell death and survival subcategory. Colored nodes refer to genes found in our dataset (green means downregulated; red means upregulated). Uncolored nodes were not identified as differentially expressed in our experiment and were integrated into the computationally generated IPA networks to indicate relevance to this network.