Research Paper Volume 13, Issue 9 pp 12378—12394

Transcriptomic profile of the mice aging lung is associated with inflammation and apoptosis as important pathways

Simulation of perturbations in senescence. Senescence signaling perturbation pathway generated by using Molecular Activity Predictor (MAP), showing downstream consequences, and predicted inferred of senescence. Colored nodes refer to genes found in our dataset (green downregulated; red upregulated). Uncolored nodes were not identified as differentially expressed in our experiment and were integrated into the computationally generated IPA networks.

Figure 5. Simulation of perturbations in senescence. Senescence signaling perturbation pathway generated by using Molecular Activity Predictor (MAP), showing downstream consequences, and predicted inferred of senescence. Colored nodes refer to genes found in our dataset (green downregulated; red upregulated). Uncolored nodes were not identified as differentially expressed in our experiment and were integrated into the computationally generated IPA networks.