Research Paper Volume 13, Issue 10 pp 14277—14288

Silencing UCHL3 enhances radio-sensitivity of non-small cell lung cancer cells by inhibiting DNA repair

UCHL3 knockdown impaired HR repair (A) Schematic diagram of HR reporter system. (B) Analysis of HR repair activity in A549 cells and H460 cells after transfected with sh-NC or sh-UCHL3. (C) Analysis of RAD51 foci in A549 cells transfected with sh-NC and sh-UCHL3 after exposure to radiation. (D) Analysis of RAD51 foci in H460 cells transfected with sh-NC and sh-UCHL3 after exposure to radiation. **P

Figure 5. UCHL3 knockdown impaired HR repair (A) Schematic diagram of HR reporter system. (B) Analysis of HR repair activity in A549 cells and H460 cells after transfected with sh-NC or sh-UCHL3. (C) Analysis of RAD51 foci in A549 cells transfected with sh-NC and sh-UCHL3 after exposure to radiation. (D) Analysis of RAD51 foci in H460 cells transfected with sh-NC and sh-UCHL3 after exposure to radiation. **P < 0.01.