Figure 6. CD45RO+CD8+ T cells effectively inhibit ccRCC progression. We co-cultured CD45RO+CD8+ T cells with Caki-2 cells for 48hours and Caki-2 cells were collected. (A, B) Different genes of Caki-2 with/without CD45RO+CD8+ T cells treated were clustering into upregulated pathways (A) and downregulated pathways (B). (C) Heatmap of oncogenic DEPs based on ssGSEA score and their clinical relationships from ccRCC patients according to CD45RO level. (D) Proliferation ability of Caki-2 cells with/without CD45RO+CD8+ T cells treated. (E) Wound healing assay was used to test the invasion ability of Caki-2 cells. (F) Electron microscope images of Caki-2 cells.