Research Paper Volume 13, Issue 11 pp 15078—15099

Mechanistic insights into the anti-depressant effect of emodin: an integrated systems pharmacology study and experimental validation

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Figure 10.

EMO treatment reversed the loss of PFC neurons in DET+VEH rats. (A, B) Neurons in the PFC were detected with Nissl staining (blue, bar = 10 μm) and quantified by ImageJ (n = 4, 3-4 slices/group). Data were expressed as the means ± SEM. ▲▲▲ p < 0.001 CON+EMO vs CON+VEH. *** p < 0.001 DET+VEH vs CON+VEH. ### p < 0.001 DET+EMO vs DET+VEH.