Research Paper Volume 13, Issue 11 pp 15078—15099

Mechanistic insights into the anti-depressant effect of emodin: an integrated systems pharmacology study and experimental validation

PPI network construction for targets of EMO against depression. (A) PPI network of EMO against depression. Nodes represent target proteins and edges represent interactions among targets. The darker the color and the larger the node, the higher the degree. The thickness of the edges represents the combined score. (B) The top 10 core targets were ranked by degree. (C) PPI network of core targets extracted from (A).

Figure 4. PPI network construction for targets of EMO against depression. (A) PPI network of EMO against depression. Nodes represent target proteins and edges represent interactions among targets. The darker the color and the larger the node, the higher the degree. The thickness of the edges represents the combined score. (B) The top 10 core targets were ranked by degree. (C) PPI network of core targets extracted from (A).