Research Paper Volume 13, Issue 11 pp 15078—15099

Mechanistic insights into the anti-depressant effect of emodin: an integrated systems pharmacology study and experimental validation

KEGG pathway enrichment analysis of EMO against depression. (A) The top 10 KEGG pathways are presented in the bubble chart. The X-axis represents the rich factor, bubble size represents the count of targets enriched in terms and the color represents the p value. (B) The PPI network of targets involved in the PI3K-Akt signaling pathway. (C) KEGG pathway-target network diagram of EMO treatment of depression. Red nodes represent target proteins and blue diamond nodes represent enriched KEGG pathways.

Figure 6. KEGG pathway enrichment analysis of EMO against depression. (A) The top 10 KEGG pathways are presented in the bubble chart. The X-axis represents the rich factor, bubble size represents the count of targets enriched in terms and the color represents the p value. (B) The PPI network of targets involved in the PI3K-Akt signaling pathway. (C) KEGG pathway-target network diagram of EMO treatment of depression. Red nodes represent target proteins and blue diamond nodes represent enriched KEGG pathways.