Figure 4. The functional connectivity (FC) alteration before and after sedation. Delineation of FCs after sedation for pre-M1 (A) post-M1 (B) and control (C) groups. Red line denoted FC ≥ 0.3 while green line denoted FC < 0.3. (D–F) Changes of FCs between M1-L and the other 9 nodes pre- and post-sedation in each group. 7 of 9, 1of 9 and 0 of 9 FCs decreased significantly (p[FDR] < .05) after sedation in pre-M1 (D) post-M1 (E) and control (F) group respectively (** P <.01, **** P <.0001).