Research Paper Volume 13, Issue 11 pp 15164—15192

Identification and validation of a novel eight mutant-derived long non-coding RNAs signature as a prognostic biomarker for genome instability in low-grade glioma

Identified and functionally interpreted genomic instability-associated lncRNAs in patients with low-grade gliomas. (A) An unsupervised clustering among 529 patients with low-grade glioma was performed based on the expression patterns of 59 candidate genomic instability-associated lncRNAs. The GS group is shown in blue on the left, whereas the GU group is shown in red on the right. (B) Box plots for somatic mutations of GS and GU groups. Cumulative somatic mutations in the GU group were significantly higher compared with those in the GS group. (C) Box plots of the expression levels of UBQLN4 in the GU and GS groups. Expression levels of UBQLN4 were significantly lower in the GU group compared with the levels in the GS group. (D) Pearson correlation coefficient analysis based genomic instability-associated lncRNA and mRNA co-expression network. (E–H) GO and KEGG functional enrichment analysis of lncRNA co-expression mRNA through.

Figure 2. Identified and functionally interpreted genomic instability-associated lncRNAs in patients with low-grade gliomas. (A) An unsupervised clustering among 529 patients with low-grade glioma was performed based on the expression patterns of 59 candidate genomic instability-associated lncRNAs. The GS group is shown in blue on the left, whereas the GU group is shown in red on the right. (B) Box plots for somatic mutations of GS and GU groups. Cumulative somatic mutations in the GU group were significantly higher compared with those in the GS group. (C) Box plots of the expression levels of UBQLN4 in the GU and GS groups. Expression levels of UBQLN4 were significantly lower in the GU group compared with the levels in the GS group. (D) Pearson correlation coefficient analysis based genomic instability-associated lncRNA and mRNA co-expression network. (EH) GO and KEGG functional enrichment analysis of lncRNA co-expression mRNA through.