Research Paper Volume 13, Issue 11 pp 15164—15192

Identification and validation of a novel eight mutant-derived long non-coding RNAs signature as a prognostic biomarker for genome instability in low-grade glioma

Evaluation of the performance of the GILncSig partial gene using two external independent CGGA mRNA-seq-693 and GSE16011 datasets. (A–B) Box plots for gene expression levels of AC064875.1 and H19 for patients at different ages ( 41 years), tumor grade, IDH1 mutation status, 1p19q chromosome union deletion status, gender and MGMT methylation status in patients from the CGGA mRNA-seq-693 set. (C) Box plots for expression of AC131097.4 for patients of different ages in the CGGA mRNA-seq-693 set. (D) Box plots for gene expression levels of FLG-AS1 for patients of different tumor grades and gender in the CGGA mRNA-seq-693 set. (E). Box plots expression level of lncRNA H19 in patients with different tumor grades and IDH1(R132) mutation status in the GSE16011 dataset.

Figure 8. Evaluation of the performance of the GILncSig partial gene using two external independent CGGA mRNA-seq-693 and GSE16011 datasets. (AB) Box plots for gene expression levels of AC064875.1 and H19 for patients at different ages (< = 41 and > 41 years), tumor grade, IDH1 mutation status, 1p19q chromosome union deletion status, gender and MGMT methylation status in patients from the CGGA mRNA-seq-693 set. (C) Box plots for expression of AC131097.4 for patients of different ages in the CGGA mRNA-seq-693 set. (D) Box plots for gene expression levels of FLG-AS1 for patients of different tumor grades and gender in the CGGA mRNA-seq-693 set. (E). Box plots expression level of lncRNA H19 in patients with different tumor grades and IDH1(R132) mutation status in the GSE16011 dataset.