Editorial Volume 13, Issue 10 pp 13376—13377

Figure 1. The EORS downward spiral of aging and Alzheimer’s (Epigenetic Oxidative Redox Shift) [2]. Yellow arrows illustrate mechanistic targets that propel the vicious cycle triggered by age-related oxidative shifts (NAD+/NADH) and age-related sedentary behavior, which elicit ROS, inflammatory stress and possibly Aβ. Green arrows indicate practical interventions to decelerate the vicious cycle and impede the progression of aging and AD.