Expression of Concern
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This article is currently under investigation. We strongly recommend that this article is not cited until the investigation is completed.
Research Paper Volume 13, Issue 11 pp 15285—15306
Mesenchymal stem cells-derived extracellular vesicles ameliorate Alzheimer’s disease in rat models via the microRNA-29c-3p/BACE1 axis and the Wnt/β-catenin pathway
Figure 3. BM-MSC-EVs carry miR-29c-3p into AD hippocampal neurons. (A) RT-qPCR was used to detect the expression of miR-29c-3p in BM-MSCs and their EVs; (B) RT-qPCR was used to detect the expression of miR-29c-3p in cerebral tissues of rats in each group; (C) RT-qPCR was used to detect the expression of miR-29c-3p in hippocampal neurons of each group; (D) AD neurons treated with PKH-26-labeled EVs were observed under a laser scanning confocal microscopy. The experiment was repeated three times, and the data was expressed as mean ± standard deviation. Data were analyzed using one-way ANOVA followed by Tukey’s multiple comparisons test. ***p < 0.001.