Research Paper Advance Articles

Cistanche deserticola polysaccharides alleviate cognitive decline in aging model mice by restoring the gut microbiota-brain axis

Prolonged administration of D-galactose induces learning and memory impairment in mice. (A, B) Novel object recognition test results show preferential index values for WT and model group mice after (A) 24 h training and (B) 1 h testing phase. (C–F) Morris water maze test results show (C) latency in learning phase, (D) latency in test phase, (E) number of plate crossings, and (F) time in the target quadrant for the WT and model group mice. Note: *p

Figure 1. Prolonged administration of D-galactose induces learning and memory impairment in mice. (A, B) Novel object recognition test results show preferential index values for WT and model group mice after (A) 24 h training and (B) 1 h testing phase. (CF) Morris water maze test results show (C) latency in learning phase, (D) latency in test phase, (E) number of plate crossings, and (F) time in the target quadrant for the WT and model group mice. Note: *p<0.05, **p<0.01, ***p<0.001 compared with the WT group mice; by. All values are represented as means ± SEM (n=15); Data was analyzed by one-way ANOVA followed by Dunnett's post hoc test.