Research Paper Volume 13, Issue 11 pp 15320—15335

Cistanche deserticola polysaccharides alleviate cognitive decline in aging model mice by restoring the gut microbiota-brain axis

CDPS treatment improves learning and memory in the D-gal aging model mice. (A) The body weights of WT, Mod, and CDPS group mice during administration. (B, C) Novel object recognition test results show the preferential index in WT, Mod, and CDPS group mice after (B) 24 h training and (C) 1 h testing phase. Morris water maze test results show (D, E) escape latency, (F) number of plate crossings, and (G) time in the target quadrant for the WT, Mod, and CDPS group mice. Note: *p

Figure 3. CDPS treatment improves learning and memory in the D-gal aging model mice. (A) The body weights of WT, Mod, and CDPS group mice during administration. (B, C) Novel object recognition test results show the preferential index in WT, Mod, and CDPS group mice after (B) 24 h training and (C) 1 h testing phase. Morris water maze test results show (D, E) escape latency, (F) number of plate crossings, and (G) time in the target quadrant for the WT, Mod, and CDPS group mice. Note: *p<0.05, **p<0.01, and ***p<0.001 compared to the WT group mice; #p<0.05, ##p<0.01, and ###p<0.001 compared to the Mod group mice. Differences between groups were analyzed by one-way ANOVA followed by the Dunnett's post hoc test. All values are shown as means ± SEM (n=15).