Research Paper Volume 13, Issue 11 pp 15320—15335

Cistanche deserticola polysaccharides alleviate cognitive decline in aging model mice by restoring the gut microbiota-brain axis


Figure 6. CDPS treatment reduces oxidative stress in the brains of D-galactose-induced aging model mice. (AE) Colorimetric assay results show (A) AOPP, (C) LOP, and (E) MDA levels as well as (B) GSH-Px and (D) SOD enzyme activities in the brain homogenates of WT, Mod, and CDPS (CH, CM, and CL) group of mice. (F) Representative images (top to bottom: 40×, 100×, 400×; scale bar=100μm) show H&E and Nissl stained brain sections of WT, Mod, and CDPS (CH, CM, and CL) group mice. Note: *p<0.05, **p<0.01, and ***p<0.001 compared to the WT group mice; #p<0.05, ##p<0.01, and ###p<0.001 compared to the Mod group mice. The data were analyzed by one-way ANOVA followed by Dunnett's post hoc test. All values are shown as means ± SEM (n=15).