Research Paper Volume 13, Issue 11 pp 15320—15335

Cistanche deserticola polysaccharides alleviate cognitive decline in aging model mice by restoring the gut microbiota-brain axis

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Figure 7.

CDPS alleviates learning and memory by restoring homeostasis of the gut microbiota. (A) Heat maps show long-term memory (preferential index*) and short-term memory (preferential index) in the WT, Mod, CM, ABX, and Cy groups of mice. (B) The relative abundance of top 10 gut microbial phyla in the WT, Mod, CDPS, ABX, and Cy groups of mice.(C) Venn diagram shows the number of bacterial operational taxonomic units (OTUs) in the WT, Mod, CDPS, ABX, and Cy groups of mice. (DI) ELISA assays show levels of TNF-α, IL-2, IL-4, IL-10, SOD, and MDA in the serum of WT, Mod, CDPS, ABX, and Cy groups of mice. (JN) Colorimetric assay results show the levels of AOPP, MDA, and LPO as well as activities of GSH-PX and SOD enzymes in the brains of WT, Mod, CDPS, ABX, and Cy groups of mice. Note: *p<0.05, **p<0.01, and ***p<0.001 compared to the WT group mice; #p<0.05, ##p<0.01, and ###p<0.001 compared to the Mod group mice. The data were analyzed by one-way ANOVA followed by the Dunnett's post hoc test. All values are represented as means ± SEM (n=15).