Figure 2. Characterization of CD4 T-cell subsets. Frequencies (median and IQR) of CD4 T-cells expressing proliferation (Ki67, A, OX40 B), metabolic-related (CD98, C), activation (HLA-DR, D, CD95, E), exhaustion/senescence (CD57, F, PD1, G CD28, H), suppression (CTLA-4, I), and gut-homing imprinting (integrin β7, J) markers. Subjects were classified according to a lower (1st tertile, <1.4), intermediate (2nd tertile, 1.4-2), or higher (3rd tertile, >2) CD4/CD8 ratio. Variables with a p-value <0.05 were considered statistically significant, as shown in bold. ns, nonsignificant.