Figure 4. Characterization of CD8 T-cell subsets. Frequencies (median and IQR) of CD8 T-cells expressing proliferation (Ki67; A), metabolic-related (CD98; B), activation (HLA-DR, CD95; C, D), exhaustion/senescence (CD57, PD1, CD28; E–G), and gut-homing imprinting (integrin β7; H) markers according to the CD4/CD8 ratio. Subjects were classified according to a lower (1st tertile, <1.4), intermediate (2nd tertile, 1.4-2), or higher (3rd tertile, >2) CD4/CD8 ratio. Variables with a p-value <0.05 were considered statistically significant, as shown in bold. ns, nonsignificant.