Research Paper Advance Articles

Identification of a nomogram based on an 8-lncRNA signature as a novel diagnostic biomarker for childhood acute lymphoblastic leukemia

Establishment and validation of the eight-lncRNA prognostic signature. (A–C) The procedure for establishing the prognostic signature. (D) Correlation between the prognostic signature and the overall survival of patients in the TCGA cohort. The distribution of signature scores (upper), survival time (middle) and lncRNA expression levels (lower). The black dotted lines represent the median signature score cutoff dividing patients into low- and high-signature score groups. The red dots and lines represent the patients in the high-score groups. The green dots and lines represent the patients in the low-score groups. (E) ROC curve analyses based on the 8-lncRNA signature. (F) Kaplan-Meier curves of OS based on the 8-lncRNA signature.

Figure 1. Establishment and validation of the eight-lncRNA prognostic signature. (AC) The procedure for establishing the prognostic signature. (D) Correlation between the prognostic signature and the overall survival of patients in the TCGA cohort. The distribution of signature scores (upper), survival time (middle) and lncRNA expression levels (lower). The black dotted lines represent the median signature score cutoff dividing patients into low- and high-signature score groups. The red dots and lines represent the patients in the high-score groups. The green dots and lines represent the patients in the low-score groups. (E) ROC curve analyses based on the 8-lncRNA signature. (F) Kaplan-Meier curves of OS based on the 8-lncRNA signature.