Research Paper Volume 13, Issue 11 pp 15569—15579

Repressor element-1 silencing transcription factor regulates glutamate receptors and immediate early genes to affect synaptic plasticity


Figure 1. Prediction of related genes associated with REST. (A) ENCODE database included 464 differentially expressed transcripts related to REST, including 2 upstream genes and 462 downstream genes. The rhomboid nodes represented REST, the v-shaped nodes were the upstream genes of REST, and the circular nodes were the downstream genes of REST. The red nodes represented up-regulated genes by REST and green nodes represented down-regulated genes by REST. (B) For the differentially expressed genes regulated by REST, synaptic functions, such as glutamatergic synapses, LTP, dopaminergic synapses, were significantly enriched as shown in the GO analysis.