Research Paper Volume 13, Issue 11 pp 14651—14674

Hippocampal transcriptome profiling reveals common disease pathways in chronic hypoperfusion and aging

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Figure 7.

Analysis of differentially expressed mRNA transcripts in different brain cells in young 30 day BCAS animals compared to old Sham animals. (A) Venn diagram of statistically significant (adjusted p-value<0.05) differentially regulated genes in the Y30D/YSham vs OSham/YSham comparison groups. The data was sorted according to cell type specificity based on a previously published database (Ref. 34) (Refer to Materials and Methods section for more details). The cell type specific profile of the genes are illustrated in six venn diagrams for each cell type including astrocytes, endothelial cells, microglia, neurons, oligodendrocytes and oligodendrocyte precursor cells (OPCs). The potential protein-protein interactions of the cell type specific genes unique for the respective experimental groups of Y30D and OSham respectively for astrocytes (B), endothelial cells (C), microglia (D), neurons (E), oligodendrocytes (F) and OPCs (G). The lines joining the different gene nodes indicate protein-protein associations such as known or predicted interactions and others such as text mining, co-expression or protein homology.