Figure 5. Reduction of Aβ and Tau immunoreactivity of SG-Tang in STZ-treated 3×Tg-AD mice. Mice in – STZ, STZ and STZ/SG-Tang groups received vehicle, STZ and STZ+SG-Tang, respectively during the course of the experiment. (A) Representative IHC images for NeuN and intensity quantification in the hippocampus of mice. DG, dentate gyrus; CA1 and CA3, Cornu Ammonis areas 1 and 3. (B, C) Representative IHC images for Aβ and Tau and intensity and area quantification in the hippocampus and cortex of mice. P values: comparisons between STZ vs. – STZ mice (#: P < 0.05, ##: P < 0.01, ###: P < 0.001), or STZ/SG-Tang vs. STZ mice (*: P < 0.05, ***: P < 0.001). (One-way ANOVA with a post hoc Tukey test).