Research Paper Volume 13, Issue 11 pp 15620—15637

Formulated Chinese medicine Shaoyao Gancao Tang reduces NLRP1 and NLRP3 in Alzheimer’s disease cell and mouse models for neuroprotection and cognitive improvement

Mitigation of NLRP1 and NLRP3 expression of SG-Tang in STZ-treated 3×Tg-AD mice. Expression levels of NLRP1 and NLRP3 in hippocampus were analyzed by Western blot using β-Actin as a loading control. To normalize, the relative NLRP1 and NLRP3 of – STZ mice was set as 100%. P values: comparisons between STZ vs. – STZ mice (###: P P P post hoc Tukey test).

Figure 6. Mitigation of NLRP1 and NLRP3 expression of SG-Tang in STZ-treated 3×Tg-AD mice. Expression levels of NLRP1 and NLRP3 in hippocampus were analyzed by Western blot using β-Actin as a loading control. To normalize, the relative NLRP1 and NLRP3 of – STZ mice was set as 100%. P values: comparisons between STZ vs. – STZ mice (###: P < 0.001), or STZ/LSG-Tang vs. STZ mice (**: P < 0.01, ***: P < 0.001). (One-way ANOVA with a post hoc Tukey test).