Research Paper Advance Articles

Association of growth hormone receptor gene variant with longevity in men is due to amelioration of increased mortality risk from hypertension

Mortality risk (hazard ratio), adjusted for age, BMI and glucose, for hypertensive subjects and normotensive subjects according to genotype of GHR SNP rs4130113 in heterozygote disadvantage model, AG vs.AA/GG. It can be seen that in men with hypertension who had a longevity-associated genotype, mortality risk was reduced to normal in that it did not differ significantly from the survival curves of normotensive men.

Figure 2. Mortality risk (hazard ratio), adjusted for age, BMI and glucose, for hypertensive subjects and normotensive subjects according to genotype of GHR SNP rs4130113 in heterozygote disadvantage model, AG vs.AA/GG. It can be seen that in men with hypertension who had a longevity-associated genotype, mortality risk was reduced to normal in that it did not differ significantly from the survival curves of normotensive men.