Research Paper Volume 13, Issue 11 pp 14862—14891

Maturation and degeneration of the human brainstem across the adult lifespan

FA, AxD, RD, MD, MWF, R1, and R2 represented as averaged participant maps calculated for three age groups. Three representative slices covering respectively the midbrain, pons, and medulla are displayed. The red bars on the anatomical images indicate the location of these slices. Visual inspection indicates an increase in R1, R2, and MWF from early adulthood, 20-29 years, through middle age, followed by a decrease in several brainstem substructures, and a more generally monotonic decrease in FA. Inspection of AxD, RD, and MD demonstrated a slight decrease from early adulthood through middle age followed by an increase in several brainstem substructures.

Figure 1. FA, AxD, RD, MD, MWF, R1, and R2 represented as averaged participant maps calculated for three age groups. Three representative slices covering respectively the midbrain, pons, and medulla are displayed. The red bars on the anatomical images indicate the location of these slices. Visual inspection indicates an increase in R1, R2, and MWF from early adulthood, 20-29 years, through middle age, followed by a decrease in several brainstem substructures, and a more generally monotonic decrease in FA. Inspection of AxD, RD, and MD demonstrated a slight decrease from early adulthood through middle age followed by an increase in several brainstem substructures.