Research Paper Volume 13, Issue 11 pp 14862—14891

Maturation and degeneration of the human brainstem across the adult lifespan

MWF, relaxation times, and DTI indices standardized and plotted as a function of age for six brainstem substructures to illustrate similarities and differences between MR metrics in the brainstem microstructural maturation and degeneration across the adult lifespan. Three white matter regions and three gray matter nuclei were chosen specifically since they demonstrated significant quadratic associations with age across all of these parameters. Diffusivity indices were inverted for easier comparisons.

Figure 4. MWF, relaxation times, and DTI indices standardized and plotted as a function of age for six brainstem substructures to illustrate similarities and differences between MR metrics in the brainstem microstructural maturation and degeneration across the adult lifespan. Three white matter regions and three gray matter nuclei were chosen specifically since they demonstrated significant quadratic associations with age across all of these parameters. Diffusivity indices were inverted for easier comparisons.