Research Paper Volume 13, Issue 19 pp 22830—22842

Inhibition of JAK2/STAT3 signaling pathway by panaxadiol limits the progression of pancreatic cancer

Panaxadiol inhibited the migration of human pancreatic cancer cells. (A–B) Wound healing assay demonstrated the migration ability of PANC and Patu8988 was inhibited by panaxadiol in a dose-dependent manner. Meanwhile, we also used serum-free medium to exclude the effect of cell proliferation on the migration experiments. (C–D) Transwell assay proved panaxadiol suppressed the migration of PANC-1 and Patu8988 cells compared to control groups after being incubated with 0, 5 μM, 10 μM panaxadiol for 24 h. *P

Figure 4. Panaxadiol inhibited the migration of human pancreatic cancer cells. (AB) Wound healing assay demonstrated the migration ability of PANC and Patu8988 was inhibited by panaxadiol in a dose-dependent manner. Meanwhile, we also used serum-free medium to exclude the effect of cell proliferation on the migration experiments. (CD) Transwell assay proved panaxadiol suppressed the migration of PANC-1 and Patu8988 cells compared to control groups after being incubated with 0, 5 μM, 10 μM panaxadiol for 24 h. *P < 0.05.