Research Paper Volume 13, Issue 19 pp 22843—22855

Allicin protects against myocardial I/R by accelerating angiogenesis via the miR-19a-3p/PI3K/AKT axis

Allicin’s effect on the MI/R was associated with increased capillary angiogenesis in the peri-infarct area. (A) Masson staining of myocardial sections showed that the numbers of neovascularization was increased in myocardium Model group compared with the Control group, and the Allicin group's capillary angiogenesis was increased compared with the Model group (*P B) Immunohistochemical staining for myocardial lactate dehydrogenase (green) and CD31(red) in the peri-infarct area showed that Compared with the Control group, the expression level of CD-31 was upregulated in myocardium Model group, while Allicin treatment further increased capillary angiogenesis compared with the Mode (*P

Figure 2. Allicin’s effect on the MI/R was associated with increased capillary angiogenesis in the peri-infarct area. (A) Masson staining of myocardial sections showed that the numbers of neovascularization was increased in myocardium Model group compared with the Control group, and the Allicin group's capillary angiogenesis was increased compared with the Model group (*P < 0.01). (B) Immunohistochemical staining for myocardial lactate dehydrogenase (green) and CD31(red) in the peri-infarct area showed that Compared with the Control group, the expression level of CD-31 was upregulated in myocardium Model group, while Allicin treatment further increased capillary angiogenesis compared with the Mode (*P < 0.01).