Research Paper Volume 13, Issue 19 pp 22843—22855

Allicin protects against myocardial I/R by accelerating angiogenesis via the miR-19a-3p/PI3K/AKT axis

MiR-19a-3p promotes angiogenesis by regulating PI3K/AKT pathway. (A–B) Compared with the control group, the expression of p-PI3K, p-AKT, p-mTOR, VEGF, Cox-2, MMP-2 were significantly decreased after miR-19α-3p mimic transfection, and further significantly increased after miR-19α-3p inhibitor transfection. (*P C) The miR-19a-3p levels of each groups.

Figure 6. MiR-19a-3p promotes angiogenesis by regulating PI3K/AKT pathway. (AB) Compared with the control group, the expression of p-PI3K, p-AKT, p-mTOR, VEGF, Cox-2, MMP-2 were significantly decreased after miR-19α-3p mimic transfection, and further significantly increased after miR-19α-3p inhibitor transfection. (*P < 0.01). (C) The miR-19a-3p levels of each groups.