Research Paper Volume 13, Issue 19 pp 22649—22665

Effects of periostin deficiency on kidney aging and lipid metabolism

Changes in lipid profiles according to kidney age and periostin expression. (A) chE and cholesterol were significantly increased in aged WT mice compared to young mice, but to a lesser extent in aged Postn-null mice. Data are the mean ± SEM. *p t-test); ***p t-test). (B, C) SM and Cer did not differ between the groups, but C1P was higher in aged WT mice than in aged Postn-null mice. Data are the mean ± SEM. **p t-test). (D) LPC was increased in all aged mice, with no difference between WT mice and Postn-null mice. In contrast, PC was significantly lower in aged Postn-null mice than in aged WT mice. Data are the mean ± SEM. **p t-test).

Figure 4. Changes in lipid profiles according to kidney age and periostin expression. (A) chE and cholesterol were significantly increased in aged WT mice compared to young mice, but to a lesser extent in aged Postn-null mice. Data are the mean ± SEM. *p < 0.05 (unpaired t-test); ***p < 0.001 (unpaired t-test). (B, C) SM and Cer did not differ between the groups, but C1P was higher in aged WT mice than in aged Postn-null mice. Data are the mean ± SEM. **p < 0.01 (unpaired t-test). (D) LPC was increased in all aged mice, with no difference between WT mice and Postn-null mice. In contrast, PC was significantly lower in aged Postn-null mice than in aged WT mice. Data are the mean ± SEM. **p < 0.01 (unpaired t-test).