Research Paper Volume 13, Issue 19 pp 22912—22933

Significance of CD8+ T cell infiltration-related biomarkers and the corresponding prediction model for the prognosis of kidney renal clear cell carcinoma

Elimination of inter-study bias in immune cell chip data. The batch effect correction of each chip was completed by the inSilicoMerging software package of Bioconductor. (A) Principal component analysis (PCA) analysis of each chip data before batch effect was removed; (B) PCA analysis of each chip data after the batch effect was removed; (C) The differential expression (|logFC|>1 and p

Figure 1. Elimination of inter-study bias in immune cell chip data. The batch effect correction of each chip was completed by the inSilicoMerging software package of Bioconductor. (A) Principal component analysis (PCA) analysis of each chip data before batch effect was removed; (B) PCA analysis of each chip data after the batch effect was removed; (C) The differential expression (|logFC|>1 and p<0.05) gene heat map of CD8 T cells and other immune cells.