Research Paper Volume 13, Issue 19 pp 22912—22933

Significance of CD8+ T cell infiltration-related biomarkers and the corresponding prediction model for the prognosis of kidney renal clear cell carcinoma

Prognostic efficacy evaluation of risk scoring model and external data verification. (A) Kaplan-Meier overall survival curve of patients in the TCGA-KIRC cohort. The abscissa axis represents survival time; the ordinate axis represents survival probability. The survival curves of different colors represent different risk score subgroups. (B) Kaplan-Meier overall survival curve of patients in the GSE22541 cohort. The abscissa axis represents survival time; the ordinate axis represents survival probability. The survival curves of different colors represent different risk score subgroups. (C) The predictive efficiency of the risk scoring model in the TCGA-KIRC cohort (AUC= 0.765). The abscissa axis represents false positive rate; the ordinate axis represents true positive rate. (D) The predictive efficiency of the risk scoring model in the GSE22541 cohort (AUC= 0.629). The abscissa axis represents false positive rate; the ordinate axis represents true positive rate. (E) Heatmap representation of the expression levels of genes included in the KIRC scoring model of the low and the high-risk groups, and the distribution of clinicopathological characteristics in the low and high-risk groups. (F) Kaplan-Meier overall survival curve of patients with KIRC in the GSE29609 cohort. The abscissa axis represents survival time; the ordinate axis represents survival probability. The survival curves of different colors represent different risk score subgroups.

Figure 3. Prognostic efficacy evaluation of risk scoring model and external data verification. (A) Kaplan-Meier overall survival curve of patients in the TCGA-KIRC cohort. The abscissa axis represents survival time; the ordinate axis represents survival probability. The survival curves of different colors represent different risk score subgroups. (B) Kaplan-Meier overall survival curve of patients in the GSE22541 cohort. The abscissa axis represents survival time; the ordinate axis represents survival probability. The survival curves of different colors represent different risk score subgroups. (C) The predictive efficiency of the risk scoring model in the TCGA-KIRC cohort (AUC= 0.765). The abscissa axis represents false positive rate; the ordinate axis represents true positive rate. (D) The predictive efficiency of the risk scoring model in the GSE22541 cohort (AUC= 0.629). The abscissa axis represents false positive rate; the ordinate axis represents true positive rate. (E) Heatmap representation of the expression levels of genes included in the KIRC scoring model of the low and the high-risk groups, and the distribution of clinicopathological characteristics in the low and high-risk groups. (F) Kaplan-Meier overall survival curve of patients with KIRC in the GSE29609 cohort. The abscissa axis represents survival time; the ordinate axis represents survival probability. The survival curves of different colors represent different risk score subgroups.