Research Paper Volume 13, Issue 19 pp 22985—23003

Vitellogenin 2 promotes muscle development and stimulates the browning of white fat


Figure 6. Fertilized egg yolk extract (FEYE) not only promotes muscle growth and development by delivering VTG2, but also stimulates the browning reaction of white fat. The green line represents a negative effect, and the red line represents a positive effect. On the one hand, VTG2 inhibits the binding of MSTN and its receptor, thereby promoting P-AKT activity and inhibiting the expression levels of Murf-1 and Atrogin-1. These pathways promote muscle growth. On the other hand, VTG2 can stimulate the expression level of PGC1α, an upstream activator of FNDC5, leading to an increase in Irisin secretion, which can promote the browning of white fat.