Research Paper Volume 13, Issue 19 pp 23036—23071

Low expression of endoplasmic reticulum stress-related gene SERP1 is associated with poor prognosis and immune infiltration in skin cutaneous melanoma

Genetic alteration and protein localization of SERP1 in SKCM patients. (A) Bar chart of SERP1 mutation in pan-cancers based on TCGA database. (B) SERP1 gene expression and mutation analysis in SKCM. (C) The distribution of SERP1 genomic alterations in SKCM. (D) The graph of the correlation between SERP1 expression and copy number alterations in SKCM. (E) Kaplan-Meier curve of OS in SKCM patients with altered (red) and unaltered (blue) mRNA expression of the SERP1 gene. (F) The representative IHC staining images from HPA database presents SERP1 expression in normal and tumor tissues.

Figure 5. Genetic alteration and protein localization of SERP1 in SKCM patients. (A) Bar chart of SERP1 mutation in pan-cancers based on TCGA database. (B) SERP1 gene expression and mutation analysis in SKCM. (C) The distribution of SERP1 genomic alterations in SKCM. (D) The graph of the correlation between SERP1 expression and copy number alterations in SKCM. (E) Kaplan-Meier curve of OS in SKCM patients with altered (red) and unaltered (blue) mRNA expression of the SERP1 gene. (F) The representative IHC staining images from HPA database presents SERP1 expression in normal and tumor tissues.