Research Paper Volume 13, Issue 19 pp 23108—23118

METTL3 regulates hippocampal gene transcription via N6-methyladenosine methylation in sevoflurane-induced postoperative cognitive dysfunction mouse

The global m6A RNA methylation in the hippocampus of POCD mice. The m6A RNA methylation levels detected by dot plot assay (A) and RIP-seq (B). The distribution of differential m6A enrichment on the entire transcriptome (C). Data are presented as the mean ± standard error of the mean of three individual experiments; p

Figure 1. The global m6A RNA methylation in the hippocampus of POCD mice. The m6A RNA methylation levels detected by dot plot assay (A) and RIP-seq (B). The distribution of differential m6A enrichment on the entire transcriptome (C). Data are presented as the mean ± standard error of the mean of three individual experiments; p < 0.05 vs. control or non-POCD groups.