Research Paper Volume 13, Issue 19 pp 23108—23118

METTL3 regulates hippocampal gene transcription via N6-methyladenosine methylation in sevoflurane-induced postoperative cognitive dysfunction mouse

Differential m6A RNA methylation at the 5′UTR in POCD. The genes with differential m6A RNA methylation at the 5′UTR in POCD mice depicted by a volcano plot. (A) The GO analysis of these genes is depicted by a bubble chart. (B) The m6A enrichment at the 5′UTR of SOX2, SYN1, BDNF, BACE1, and IL17A in POCD mice depicted by IGV. (C) The mRNA levels of SOX2, SYN1, BDNF, BACE1, and IL17A in POCD. (D) The m6A enrichment at the 3′UTR of CCND2, STAR, and TIGAR in POCD shown by IGV. (E) The mRNA levels of CCND2, STAR, and TIGAR in POCD. (F) Data are presented as the mean ± standard error of the mean of three individual experiments; p

Figure 2. Differential m6A RNA methylation at the 5′UTR in POCD. The genes with differential m6A RNA methylation at the 5′UTR in POCD mice depicted by a volcano plot. (A) The GO analysis of these genes is depicted by a bubble chart. (B) The m6A enrichment at the 5′UTR of SOX2, SYN1, BDNF, BACE1, and IL17A in POCD mice depicted by IGV. (C) The mRNA levels of SOX2, SYN1, BDNF, BACE1, and IL17A in POCD. (D) The m6A enrichment at the 3′UTR of CCND2, STAR, and TIGAR in POCD shown by IGV. (E) The mRNA levels of CCND2, STAR, and TIGAR in POCD. (F) Data are presented as the mean ± standard error of the mean of three individual experiments; p < 0.05 vs. control group.