Figure 2. Identification of CASEs in PTC. (A) Volcano plot of CASEs identified in PTC (log2FC > 0.1, adjusted P < 0.05). (B) Heatmap of the CASEs between matched tumor and adjacent normal tissues of 50 PTC patients. (C) Interactive sets among seven AS types of CASEs (n = 1,925) shown in an UpSet plot. (D) The representative CASEs, derived from the same parent gene and exhibited the opposite preference between tumor and adjacent normal tissues, were shown. Student’s t-test was used. (E) Venn diagram of CASEs and DEGs. (F) Interactive sets of AP/AT events and DEGs shown in UpSet plot. ES, exon skipping; AP, alternate promoter; AT, alternate terminator; AD, alternate donor; AA, alternate acceptor site; ME, mutually exclusive exons; RI, retained intron.