Research Paper Volume 13, Issue 19 pp 23149—23168

Comprehensive analysis of aberrant alternative splicing related to carcinogenesis and prognosis of papillary thyroid cancer

Interaction analysis of CASEs. (A) PPI network analysis of CASEs generated by Cytoscape. Nodes indicate parent genes with CASEs, while edges represent the potential interactions between the corresponding proteins. The shape, size, and color of nodes denote AS types, the value of log2FC, and change patterns, respectively. ES, exon skipping; AP, alternate promoter; AT, alternate terminator; AD, alternate donor; AA, alternate acceptor site; ME, mutually exclusive exons; RI, retained intron. (B) Hub genes ranked by MCC. (C) Module 1 was correlated with tumorigenesis. (D) Module 2 was correlated with extracellular matrix.

Figure 4. Interaction analysis of CASEs. (A) PPI network analysis of CASEs generated by Cytoscape. Nodes indicate parent genes with CASEs, while edges represent the potential interactions between the corresponding proteins. The shape, size, and color of nodes denote AS types, the value of log2FC, and change patterns, respectively. ES, exon skipping; AP, alternate promoter; AT, alternate terminator; AD, alternate donor; AA, alternate acceptor site; ME, mutually exclusive exons; RI, retained intron. (B) Hub genes ranked by MCC. (C) Module 1 was correlated with tumorigenesis. (D) Module 2 was correlated with extracellular matrix.